Python Programming On Win32: Help for Windows Programmers

Python with pywin32 [1] was also, and still is, a pretty good way to work with COM APIs. There is a book on it [2] from twenty years ago that is still surprisingly applicable.

[1] https://www.amazon.com/Python-Programming-Win32-Windows-Prog...

What I can recommend if you are okay with buying a book is this guide.

The documentation(can also be found in the installation of PyWin32) and Active State's doc(with their list of objects and modules) should do the rest.

Python Programming On Win32 from O'Reilly is a great, if dated, book on the subject. I've read it and is very good.

Its not documentation, per se, but its really useful for a good introduction to COM programming with Python, among other advanced stuff.