The First American: The Life and Times of Benjamin Franklin

I started with that one - I liked Isaacson's writing when I read his Steve Jobs biography, so I decided to read his Franklin bio as well. I very much enjoyed it. Afterward, I read this one:

https://www.amazon.com/First-American-Times-Benjamin-Frankli...

I think this one is probably where I read about his time with Hume. I don't find H.W. Brands' writing to be quite as smooth to read as Isaacson's, but I remember him covering parts of Franklin's life in greater detail. His bio of Ulysses Grant was a great read, too:

https://www.amazon.com/Man-Who-Saved-Union-Ulysses/dp/030747...